APPLICATIONS
Particle processing can be overwhelming. Before you buy, our sister company XEDEV can work with you to show you the most suitable PROCEPT equipment for your process applications.
Particle engineering is our speciality!
Modified/ Controlled/ Sustained Release
Targeting specific parts of the body with active ingredients.
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A Modified release formulation is a mechanism that delivers an active ingredient with a delay or for a prolonged period or to a specific target in the body. A Sustained or Controlled release formulation releases an active ingredient in a constant rate for a specific period of time.
PROCEPT Equipment for modified release
Spray Dryer R&D Spray Chiller Spray Dryer GMP Priller Fluid Bed Pan Coater High Shear Granulator Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Solubility Enhancement
70% of the new synthesized small molecules are poorly soluble compounds.
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70% of the new synthesized small molecules are poorly soluble compounds, resulting in a low bioavailability. Bioavailability enhancement is the number one challenge in API formulation development today.
One of the main approaches to increase the solubility is by creating an amorphous solid dispersion, which can be created by different technologies such as spray-drying, spray-congealing, fluid bed bead coating, Hot melt extrusion. After processing, the API is dispersed on molecular level in a polymeric matrix. The polymer is used to stabilize the amorphous, metastable form of the drug and to sustain supersaturation of the API in biological fluids, thereby increasing the bioavailability.
PROCEPT Equipment for Solubility Enhancement
Spray Dryer R&D Spray Chiller Spray Dryer GMP Fluid Bed Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Flowability
Important for powder handling and transport.
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The agglomeration process is used to improve the powder flowability, required for powder handling, transport, compression, capsule filling and sachet filling. Besides the flowability improvement by agglomeration, the fine dust fraction will be reduced. Core shell encapsulation by spray drying can also be applied to improve the flowability by adding an extra layer around the particles that can decrease the cohesiveness between particles
PROCEPT Equipment for Flowability
Fluid Bed High Shear Granulator Twin Screw Extruder Spray Dryer R&D Spray Chiller Spray Dryer GMP
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Reconstitution
Enhancement of the shelf life of compounds by processing into a powder first.
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Some active compounds lose their activity in a short time, when prepared in a liquid dosage and require extreme cold chain conditions. To enhance the shelf life even to 24 months, the active can be formulated and processed into a dry powder form, so that it can be reconstituted at the moment of administration.
PROCEPT Equipment for Reconstition
Spray Dryer R&D Spray Dryer GMP Fluid Bed High Shear Granulator Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Encapsulation
Intended for different applications such as gastric pH protection of ingredients.
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Core shell encapsulation of an active ingredient or when the final dosage form is intended for different applications such as protection against gastric pH, protection against the environment (moisture, temperature or light) or improvement of flowability, by decreasing cohesiveness.
PROCEPT Equipment for Encapsulation
Spray Dryer R&D Spray Chiller Spray Dryer GMP Fluid Bed Plasma Fluid Bed Pan Coater
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Stabilisation
Prevent physical and chemical degradation prior to administration.
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Mainly biologics are very sensitive to environmental conditions and will need to be formulated and processed to prevent physical and chemical degradation prior to administration.
PROCEPT Equipment for Stabilization
Spray Dryer R&D Spray Chiller Spray Dryer GMP Fluid Bed Mi-Pro High Shear Granulator Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Inhalation
The optimal aerodynamic diameter of particles for inhalation is between 1 – 5 µm.
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For efficient drug deposition within the lungs the optimal aerodynamic diameter of particles for inhalation is between 1 – 5 µm. Spray-drying is the ideal drying process to generate these inhalation particles as the process allows precise control over the particle size and shape, generating powders with narrow particle size distributions and low particle surface energy.
PROCEPT Equipment for inhalation
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Compressability
Necessary for the formulation mixture to be able to be formed into a tablet.
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A tablet formulation contains different compounds; active(s) and excipient(s), with different density, shape and size. In order to make an homogenous, flowable and compressible tablet from this formulation mixture, agglomeration of these compounds is required.
PROCEPT Equipment for Compressibility
Fluid Bed High Shear Granulator Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Taste Masking
Used to achieve patient compliance for bitter or unpleasant tasting ingredients.
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Taste-masking formulations are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients to achieve patient compliance. Pediatrics and geriatrics are not always able to swallow tablets or capsules, therefore the oral formulation is dispersed into food or drinks whereby the unpleasant taste is often the biggest barrier for these patient groups.
PROCEPT Equipment for Taste Masking
Spray Dryer R&D Spray Chiller Spray Dryer GMP Priller Fluid Bed Pan Coater High Shear Granulator Twin Screw Extruder
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev.
Washing
Remove unwanted residual solvents prior to the drying step.
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To remove different solvents, downstream a process like crystallization, a filtration washing step is applied. The crystals are being filtered and remain within the process reactor that is flushed with different solvents in order to remove residual solvents to be avoided prior to the drying step.
PROCEPT Equipment for Washing
Our XEDEV scientific expert team can support you in the development of your formulation, process, scale-up, clinical production and more… Interested? Click here for more info on Xedev